(1R,12R)-1,5,5a,7,7aα,11,11aβ,11b-Octahydro-1β,11β-dihydroxy-5aβ,8,11bα,12-tetramethyl-2β,5β-methanonaphth[1,2-d]oxepine-4,6,10(2H)-trione
Eurycomalactone
CAS: 23062-24-0
Molecular Formula: C19H24O6
(1R,12R)-1,5,5a,7,7aα,11,11aβ,11b-Octahydro-1β,11β-dihydroxy-5aβ,8,11bα,12-tetramethyl-2β,5β-methanonaphth[1,2-d]oxepine-4,6,10(2H)-trione - Names and Identifiers
(1R,12R)-1,5,5a,7,7aα,11,11aβ,11b-Octahydro-1β,11β-dihydroxy-5aβ,8,11bα,12-tetramethyl-2β,5β-methanonaphth[1,2-d]oxepine-4,6,10(2H)-trione - Physico-chemical Properties
| Molecular Formula | C19H24O6 |
| Molar Mass | 348.39 |
| Density | 1.328±0.06 g/cm3(Predicted) |
| Melting Point | 267～270℃ |
| Boling Point | 588.1±50.0 °C(Predicted) |
| pKa | 12.22±0.70(Predicted) |
| Storage Condition | 2-8℃ |
(1R,12R)-1,5,5a,7,7aα,11,11aβ,11b-Octahydro-1β,11β-dihydroxy-5aβ,8,11bα,12-tetramethyl-2β,5β-methanonaphth[1,2-d]oxepine-4,6,10(2H)-trione - Reference Information
| biological activity | Eurycomalactone is a natural product and is an effective NF-κB inhibitor with an IC50 value of 0.5 μM. Eurycomalactone inhibited protein synthesis and decreased cyclin D1 protein levels, but had no effect on TNFα-induced degradation of IκBα or phosphorylation levels of IKKα/β and IκBα. |
| target | IC50: 0.5 μM (NF-κB) |
Last Update：2024-04-09 20:52:54
![(1R,12R)-1,5,5a,7,7aα,11,11aβ,11b-Octahydro-1β,11β-dihydroxy-5aβ,8,11bα,12-tetramethyl-2β,5β-methanonaphth[1,2-d]oxepine-4,6,10(2H)-trione](http://res.chembk.com/assets/images/structure/130231.png)
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Product Name: Eurycomalactone Visit Supplier Webpage Request for quotationCAS: 23062-24-0
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View History
(1R,12R)-1,5,5a,7,7aα,11,11aβ,11b-Octahydro-1β,11β-dihydroxy-5aβ,8,11bα,12-tetramethyl-2β,5β-methanonaphth[1,2-d]oxepine-4,6,10(2H)-trione
1261907-85-0
bta-D-Glucofuranosiduronicacid,2-propenyl,gamma-lactone(9CI)
4-Methyl-6-chloropyrimidine
3-Butenoic Acid tert-Butyl Estertert-Butyl VinylacetateVinylacetic Acid tert-Butyl Ester
N-OCTYL BROMIDE
357-69-7
592552-16-4
hycamptamine
Polymannuronic acid sodium salt
1261907-85-0
bta-D-Glucofuranosiduronicacid,2-propenyl,gamma-lactone(9CI)
4-Methyl-6-chloropyrimidine
3-Butenoic Acid tert-Butyl Estertert-Butyl VinylacetateVinylacetic Acid tert-Butyl Ester
N-OCTYL BROMIDE
357-69-7
592552-16-4
hycamptamine
Polymannuronic acid sodium salt